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Precision Prostate Biopsy at Our Los Angeles Center

A prostate biopsy is typically performed after abnormalities are discovered in a Prostate-Specific Antigen (PSA) test (where blood is tested for the levels of the PSA protein) or digital rectum exam. The biopsy is a test to remove small samples of prostate tissue that will be examined for the presence of cancer. If the results return positive for cancer, the tumor samples will be graded using the Gleason grading system. The Gleason grading system ranks the stage of prostate cancer. A higher number represents a more aggressive cancer and less promising prognosis.

To perform a prostate biopsy, a thin, hollow needle is inserted through the rectum, urethra or perineum to collect a sample of the prostate gland. The rectal approach is most common. If a prostate biopsy is done through the rectum, an enema may be necessary prior to the procedure. A sedative medicine is usually administered about an hour before the biopsy.

University of Southern California urologists have developed an innovative, 3D image-based prostate mapping biopsy technique that utilizes multi-parametric MRI/real-time TRUS image-fusion guidance. This allows them to perform precisely targeted biopsies to suspicious prostate lesions identified on the imaging. The precise intra-prostatic location of a given cancer lesion or a needle biopsy location can now be documented with millimeter accuracy. USC urologists have developed the ability to precisely record and revisit with high accuracy any geographical site of biopsy-proven cancer lesion within the prostate. Such capability up until now has not been available. These high-precision biopsies allow for more individualized decision-making based on “per prostate lesion” in patients selected for focal therapy or active surveillance.

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